pentobarbital will lessen the level or impact of conjugated estrogens by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

pentobarbital will reduce the level or impact of bortezomib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.

Monitor Intently (1)pentobarbital will decrease the level or effect of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Coadministration of fentanyl with CYP3A4 inducers could lead on to your decrease in fentanyl plasma concentrations, deficiency of efficacy or, quite possibly, progress of a withdrawal syndrome in a client that has designed Bodily dependence to fentanyl. Following halting a CYP3A4 inducer, because the effects of the inducer decrease, the fentanyl plasma concentration will increase which could raise or prolong both equally the therapeutic and adverse effects.

pentobarbital will lessen the extent or outcome of finasteride by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unknown.

CYP3A4 inducers may perhaps increase the formation with the neurotoxic/nephrotoxic ifosfamide metabolite, chloroacetaldehyde. Intently observe people having ifosfamide with CYP3A4 inducers for toxicities and consider dose adjustment.

pentobarbital will lower the extent or impact of fentanyl intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead to a minimize in fentanyl plasma concentrations, insufficient efficacy or, perhaps, progress of a withdrawal syndrome inside of a patient who may have created Actual physical dependence to fentanyl.

benzhydrocodone/acetaminophen and pentobarbital the two boost sedation. Stay away from or Use Alternate Drug. Restrict use to sufferers for whom substitute remedy alternatives are inadequate

pentobarbital will website reduce the level or outcome of tolterodine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

pentobarbital will lessen the level or outcome of zolpidem by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unidentified.

pentobarbital will minimize the extent or outcome of diazepam buccal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Strong or average CYP3A4 inducers may perhaps improve level of diazepam elimination; therefore, efficacy of diazepam could be reduced.

pentobarbital will reduce the level or outcome of atazanavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown.

With therapeutic doses of TCAs, barbiturates maximize metabolism and decrease blood concentrations of TCAs.

pentobarbital will minimize the level or outcome of nilotinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.

pentobarbital will decrease the extent or outcome of vinorelbine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unidentified.